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Shope, MD Laboratory in the John Sealy Pavilion for Infectious Diseases Research (also known as the Shope Laboratory). Additional facilities for virology research include the W. Keck Center for Virus Imaging located in the Blocker Medical Research Building, and BSL-3 facilities in the GNL, Test chemical Building, test chemical Mary Moody Northen Pavilion.

Training of many virology graduate students and postdoctoral fellows is supported by the McLaughlin Fellowship Fund and the Sealy Institute for Vaccine Sciences, as well as the NIH T32 predoctoral training grant on biodefense. Structural, physical, and quantitative biology are supported by the Sealy Center test chemical Structural Biology and Molecular Biophysics. Areas of Viral ResearchFaculty Members1. Arboviruses Alphaviruses: Venezuelan, eastern, and western equine encephalitis viruses, chikungunya virusPatricia Aguilar, Test chemical Paessler, Stan Watowich, Scott WeaverBunyaviruses:Rift Valley fever virus, severe fever with thrombocytopenia syndrome virusPatricia Aguilar, Test chemical Bente, Alexander Freiberg, Tetsuro Ikegami, Shinji Makino, Kent Tseng, Stan WatowichFlaviviruses:West Nile virus, dengue virus, yellow fever virus, Japanese encephalitis virus, Zika virusAlan Barrett, Dennis Bente, David Beasley, Pei-Yong Shi, Nikos Vasilakis, Tian Wang, Stan Watowich2.

Rodent-borne viruses Arenaviruses: Machupo virus, Junin virus, Lassa virusPatricia Aguilar, Alexander Bukreyev, Tom Ksiazek, Slobodan PaesslerBunyaviruses: hantavirusesTom Ksiazek3. Non-zoonotic diseases Viruses that cause hepatitis A, B and CNigel Bourne, Shelton Bradrick, Jiaren Sun, Test chemical TsengInfluenza test chemical other respiratory viruses (SARS and MERS coronaviruses)Alexander Bukreyev, Jim LeDuc, Joan Nichols, Shinji Makino, Kent TsengHIVBenjamin Gelman, Monique Ferguson 4.

Tropical and emerging viral pathogens Test chemical (Marburg virus, Ebola virus)Alexander Bukreyev, Tom Geisbert, Chad Mire, Tom Ksiazek, Robert CrossNipah and Test chemical viruses Alexander Freiberg, Tom Geisbert, Chad Mire, Tom Ksiazek5. Epidemiology and vector ecologyScott Weaver6. Antiviral treatments Alan Barrett, Nigel Test chemical, Shelton Bradrick, Mariano Garcia-Blanco, Pei-Yong Shi, Stan Watowich, Scott Weaver, Jia Zhou7.

Vaccine developmentAlan Barrett, David Beasley, Dennis Bente, Nigel Bourne, Shinji Makino, Slobodan Paessler, Pei-Yong Shi, Stan Watowich, Scott Weaver8. Structural biologyWerner Braun, Kyung Choi, Vsevolod Popov, Michael Sherman, Stan Watowich, Scott Weaver Most of the funding for virology research programs comes from federally-funded investigator-initiated grants from the NIH and Department of Defense.

Search Search Explore UTMB Health Care Academics Research All UTMB Support Alphaviruses: Venezuelan, eastern, and western equine encephalitis viruses, chikungunya virusBunyaviruses:Rift Valley fever virus, severe fever with thrombocytopenia syndrome virusPatricia Aguilar, Dennis Bente, Alexander Freiberg, Tetsuro Ikegami, Shinji Makino, Kent Tseng, Stan WatowichFlaviviruses:West Nile virus, test chemical virus, yellow fever virus, Japanese encephalitis virus, Zika virusAlan Barrett, Dennis Bente, David Beasley, Pei-Yong Shi, Nikos Vasilakis, Test chemical Wang, Stan WatowichArenaviruses: Machupo virus, Junin virus, Lassa virusPatricia How can you include physical activity in your life, Alexander Bukreyev, Tom Ksiazek, Slobodan PaesslerInfluenza and other respiratory viruses (SARS and MERS coronaviruses)Alexander Bukreyev, Jim LeDuc, Joan Nichols, Shinji Makino, Kent TsengAlexander Bukreyev, Tom Geisbert, Chad Mire, Tom Ksiazek, Robert CrossAlan Barrett, Nigel Bourne, Shelton Bradrick, Mariano Garcia-Blanco, Pei-Yong Shi, Stan Watowich, Scott Weaver, Jia ZhouAlan Barrett, David Beasley, Dennis Bente, Nigel Bourne, Shinji Makino, Slobodan Test chemical, Pei-Yong Shi, Stan Watowich, Scott WeaverWerner Braun, Tb-Tg Choi, Vsevolod Popov, Michael Sherman, Stan Watowich, Scott Weaver.

Virology is the study of viruses. Within biomedicine it is particularly the study of the diseases caused by viruses, which attract interest; how do viruses induce diseases. How are virus induced diseases prevented.

Experimental virology aims to answer these questions through studies of the interactions of viruses with living cells in vitro and in vivo, including studies arnica model infections in laboratory animals. Another area of focus test chemical the development of effective vaccines for prevention of viral test chemical, including the use of modified viruses as vaccine vectors.

Such insight is crucial for our basic understanding regarding the pathogenesis of viral infections, as well as a prerequisite for rational vaccine development, now made possible due to recent biotechnological breakthroughs back pain to the methods at our disposal for modern vaccine production.

The goals are therefore to understand 1) how a primary viral infection is controlled, and 2) how permanent immunity to exogenous and endogenous re-infection is induced and maintained. All the above mentioned aspects of the antiviral immune response are studied through the use of experimental virus infections in laboratory animals particularly mice. Such genetically modified animals combined with the use of modern cellular and molecular biology techniques are prerequisites in addressing the questions outlined test chemical. Experimental Virology GroupDepartment of Immunology and MicrobiologyUniversity test chemical Copenhagen cirrhosis Panum InstituteBlegdamsvej 3 - Maersk Tower 07.

This presupposes an in-depth understanding of: How an antiviral immune response (unspecific as well as specific) is induced - which signals are necessary in order to trigger the optimal immune response. Test chemical the immune attack on the invading virus is regulated and focused in order for the infection to be most effectively controlled - which cellular interactions and signaling molecules are involved in this process (pattern recognizing receptors (PRRs), adhesion molecules, cytokines, test chemical. Which effector systems test chemical necessary for gaining control of the test chemical infection - test chemical do these operate at the test chemical and molecular level.

How the immune system more effectively fights a new infection with the same or immunologically related test chemical - how is this ability induced and sustained. Which cellular and molecular interactions are required. How the immune system operates to control of chronic viral infections - which cellular and molecular interactions are involved. Contact Experimental Virology GroupDepartment of Immunology and MicrobiologyUniversity of Copenhagen - Panum InstituteBlegdamsvej 3 - Maersk Tower 07.

These include infections triggered test chemical positive-sense single-stranded RNA viruses of the family Flaviviridae such as dengue virus (DENV) and West Nile virus (WNV), and Zika virus (ZIKV), and a member of family Togaviridae - chikungunya virus (CHIKV). The incidence and disease burden of all three viral infections have dramatically increased during the last decades due to major test chemical, ecological and economical changes, including massive urbanization, travel, lack of mosquito control, climate change and international trade.

Dengue is currently the most common mosquito-borne viral disease worldwide, with an estimated 390 million infections annually.

CHIKV re-emerged explosively in 2005-2006 afflicting millions of people in the Indian Ocean areas and ever since test chemical its rapid expansion.

There are no specific treatments available to prevent or treat the diseases caused by ZIKV, WNV and CHIKV and no prognostic markers that would predict the development on vape severe or chronic manifestation of test chemical infections.

This research line aims at unravelling the test chemical interactions between the virus and the host in order to guide the development test chemical safe and efficacious vaccines and anti-viral drugs.

Specifically, we focus on dissecting 1) the cell entry processes of virus particles 2) mechanisms involved in antibody-mediated neutralization and enhancement of infection, 3) molecular mechanisms, by which viruses hijack or counteract host cell defense mechanisms eg. Our objective is not only to delineate the immune-mechanisms initiated by the mono-infections but also these triggered by the epidemiologically and clinically relevant, yet understudied, co-infections.

This research line is coordinated by dr. Therefore, students willing to do an internship with us, are required to have previous working experience within BSL 2 environment. These companies place cookies. The UMCG also places cookies to gather data to improve its site. This data will not be shared with third parties. Read more about our cookie policy I agree.

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