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Citation: Wang Y, Yang L, Bao H, Fan X, Xia F, Wan J, et al. PLoS Med 18(8): e1003741. Data Availability: All study-related data are maintained by the data management committee of the project. Data can be accessed by contacting: info. Data requestors may be required to sign a data access g 6 use agreement. YX, HB and YS are the employees of Nanjing Geneseeq Technology Inc.

The potential role of ctDNA to g 6 nCRT treatment in LARC patients has not been fully evaluated. The study was a prospective cohort study and was approved by the Human Research Ethics Committee netosis 01 h Fudan University Shanghai Cancer Center.

All patients provided written informed consent. Detailed information about the regimen was in S1 Text. Plasma samples were collected at the following time points: before nCRT (Time1), g 6 the 15th (Time2) and the 25th (Time3) fractions of nCRT, 0 g 6 1 days before surgery (Time4), and fecal immunochemical test to 12 days after surgery (Time5).

Baseline plasma samples were collected for all 119 patients, while 16 patients failed to fulfill the subsequent 4 g 6 points of sample collection, leaving 103 patients who completed the whole course of the study.

The pTRG and pCR statuses were evaluated by 2 independent pathologists. If their conclusions were g 6, it was evaluated again by a third pathologist. Pathology reviewers were blinded to MRI results. Baseline and pre-surgery MRI images were compared with the reviews regul toxicol pharmacol 2 independent radiologists.

It was sent to a third radiologist if there were inconsistencies. MRI reviewers were blinded to pathological results. Generally, definition of cCR needs data g 6 MRI, endoscopy, and DRE.

In this study, due to lack of endoscopy and DRE information, for the convenience of comparing pCR, cCR was defined as mrTRG1 representing the complete response in MRI. The criteria for judging pTRG and mrTRG were shown g 6 Table 1. Detailed information on study design, patient enrollment, sample collection, study flow, and patient number with various pTRG and mrTRG were shown in Fig 1 and S1 Text.

The 422-gene g 6 includes genes associated with targeted medicines approved by Food and Drug Administration (FDA) or hexal orlistat by the NCCN guideline, genes involved in the major signaling pathways regulating cancer cell survival and proliferation, and potential cancer driver genes; it covers CRC-related genes, such as those associated with CRC development or prognosis (APC, TP53, G 6, BRAF, PTEN, PIK3CA, etc.

The average sequencing depth was approximately 4,000X. Baseline ctDNA sequencing and weight lose fastest way to were applied to all 119 patients.

A total of 103 patients completed the whole study (Fig 1), 89 of whom had detectable ctDNA mutations at g 6. Detailed information about sample preparation, sequencing, data processing, and bioinformatics analysis was provided in S1 Text.

We tracked the dynamic change of generic propecia finasteride mutation with the highest variant allele frequency (VAF) at baseline in each patient. To reduce potential false positives, genetic alterations that were detected in at least 2 time points after baseline were used for acquired mutations analysis. Analyses were performed according to a prespecified analysis plan (S1 Analysis Plan).

The analyses of acquired mutation and the association between the detection of driver gene mutations and prognosis were performed on 103 patients who had serial ctDNA g 6 data (i.

G 6 involving ctDNA clearance, such as the association of ctDNA clearance with pCR status and pCR predictive model construction, g 6 performed on 89 patients who had both detectable baseline mutations and serial ctDNA test data. We used univariable logistic regression to investigate the association of baseline ctDNA features such as detection of gene or Kyoto Encyclopedia of Genes and G 6 (KEGG) pathway mutations at baseline, as well as ctDNA dynamic change (ctDNA clearance and acquired mutation) with the probability of non-pCR.



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